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Memory Mender Can Rejuvenate Damaged Cells.

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Memory Mender regenerates the mind

Memory Mender repairs the principal cells of the brain, the neurons, that store and analyze our memories, along with the glial cells (which insulate the neurons).  These amazing components of our brain function and life are responsible for orchestrating all the operations

of the brain.  From these brain cells arise our diverse abilities to contemplate the totality of the universe, or investigate the very nature of how our neurons actually perform their incredible tasks

The body natural produces Memory Mender

Memory Mender occurs naturally in the body and works by supplying cytidine and choline to the brain cells.  Memory Mender is a pure organic molecule made by combining Vitamin Bp and enzymes, which yields the nucleotide Choline Cytidine 5’-pyrophosphate.  This molecule is polarized with a molecular weight of 488.33.  Its appearance is a white crystalline structure, which is highly soluble in water allowing for quick absorption into the blood-stream and subsequent crossing into the blood brain barrier.  There is no depreciable difference between the two delivery mechanisms -- intravenous or oral, as far as the delivery systems are concerned.

Memory Mender provides choline for bio-synthesis of the neurotransmitter acetylcholine, and stimulation of tyrosine-hydroxylase activity.  Tyrosine-hydroxylase is the enzyme that is required for synthesis of neurotransmitters in the sympathetic nervous system (noradrenaline) which also aids in the release of dopamine and growth hormones.  The decline of growth hormone levels as we age contributes to decrease in bone mass, muscle mass, and strength.  The decrease in growth hormone is also associated with age-related cognitive impairments.

Memory Mender is a Neuroprotective Agent

Memory Mender has shown neuroprotective effects in situations of low brain oxygen injury (hypoxia and ischemia) by stabilizing cell membranes and reducing free radical generation, as well as improving learning and memory performance in humans and animal models of aging brains.  Furthermore, it has been demonstrated that Memory Mender restores the activity of mitochondrial ATPase

(the enzymatic form of ATP), and membranes utilizing Na+ /K+ATPase, that inhibit the activation of phospholipase-A2 (an enzyme that catalyzes the hydrolysis of a lecithin to lysolecithin by removing the 2-acyl group), and accelerates the re-absorption of cerebral edema fluids (swollen brain tissue) in various test subjects.

Increasing Blood Brain Circulation

Memory Mender has been Proven to be extremely effective in the elderly, increasing blood brain circulation, with ailments such as Alzheimer’s disease, and for enhancing mental performance in healthy young adults

and elders.  As we age, the mechanism that allows the brain membrane to be repaired becomes compromised, which is another reason to take Memory Mender nutritional supplement.

How Mush is needed

Q:        How Much Memory Mender is needed?

A:        One should take between 750- 2,000 mg. per day

Harvard Medical School Study

In a study at the Harvard Medical School healthy, older subjects who took 500 mg. of Memory Mender for six weeks had an increase of phosphotidylcholine in the brain and improved their scores on the California Verbal Learning Test.

While Memory Mender improved memory delayed recall on logical memory tests in studies, the lower dose (750 mg/day) benefited only those with relatively inefficient memories.  In the other studies, the higher dose (2,000 mg/day) was clearly associated with improved immediate and delayed logical memory.

One does not need memory loss before one uses Memory Mender.  You can take a pro-active approach to protect your memories into

the future.  The studies found Memory Mender to be of benefit not only for those with pronounced memory problems, but also for those individuals with little-to-no perceivable decline in memory function.  In the two controlled trials, daily doses of 1,200 mg of Memory Mender improved the immediate recall and attention in a group of young adult males (ages 19-38) compared with a placebo.  In middle-aged and elderly subjects, Memory Mender supplementation improved reaction time by supporting energy generation and electrical coordination in the brain.

In studies of older patients with vascular dementia, 1,200 mg per day of Memory Mender helped improve cognition, as well as emotional state, reducing confusion, and apathy.

Prevention is the Key

The body and brain start to age and lose functions as we pass maturity.  One would think this happens later in life, however this is not the case.  We lose valuable short- and long-term memories, thoughts, ideas, and forget what we are doing while we are in the middle of the action, then feel anxious because we knew we were doing something we forgot.  But what?  Ideally, Memory Mender should be used before there is a major problem like this.  Since aging is a process, and

neurotransmitter loss is slow and never ending, Memory Mender will produce the best results when taken early on in life.

With such ailments as Alzheimer or Parkinson diseases, one already has massive brain cell loss which nothing can completely reverse.  So after-the-fact treatment is much more difficult than earlier prevention.

 

Function and Application of Memory Mender:

  • Aids in the brain’s recovery following surgery, injury, and even coma.
  • Reduces blood pressure
  • Curbs Alcohol cravings
  • Promotes positive changes in lymphocyte cell count which reflects immune readiness
  • Improves memory & cognitive performance
  • Improves patients with Alzheimer’s disease
  • Improves patients with dementia

Alzheimer

Alzheimer disease is a progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in

several areas of the brain which leads to loss of cognitive function such as memory and language.

Dementia

Dementia is an organic (i.e. lack of vital nutrients to the brain) mental disorder characterized by a general loss of intellectual abilities involving impairment of memory, judgment, and abstract thinking as well as changes in personality. Dementia may be caused by a large number of conditions, some reversible and some progressive, that cause widespread cerebral and damage of dysfunction. The most common cause of

Dementia is Alzheimer’s disease, others are cerebrovascular disease (multi infarct dementia), central nervous system infection, brain trauma or tumors, pernicious anaemia, folic acid deficiency, Wernicke Korsakoff syndrome, normal pressure hydrocephalus, and neurological diseases such as Huntington disease, multiple sclerosis and Parkinson’s disease.

Improves memory and learning ability in young and old.

Counteracts brain aging by increasing cholinergic receptor sites, restoring the bioavailability of acetylcholine, increasing nerve growth factor receptors in the brain, and slowing down undesirable structural damages to the brain.

  • Counters the age-related loss of nerve cells and fibers in the brain
  • Improves memory
  • Protects the brain and other organs against toxic waste buildup of fat.
  • Increases growth hormone secretion in both the young and the old.

Supports patients recovering from cerebral ischemic attacks… ischaemia is a condition of low oxygen state usually due to obstruction of the arterial blood supply of inadequate blood flow leading to hypoxia in the tissue.

Increases the release of dopamine, the neurotransmitter that plays a major role in defeating Parkinson’s disease… Dopamine is a catecholamine neurotransmitter and hormone, formed by decarboxylation of dehydroxyphenylalanine (dopa), a precursor of adrenaline and noradrenaline.

Improves the emotional state, confusion, and apathy by preserving cardiolipin (an exclusive inner mitochondrial membrane component) and sphingomyelin by preserving the arachidonic acid content of PtdCho and phosphatidylethanolamine;

Stimulates glutathione synthesis and glutathione reductase activity; attenuating lipid peroxidation

Restores enzyme/ mineral Na(+)/K(+)-ATPase activity.

 

Double-Blind Clinical Trials With Oral Memory Mender

METHODS: A systematic search of all prospective, randomized, placebo-controlled, double-blind clinical trials with oral Memory Mender (Medline, Cochrane, and Ferrer Group bibliographic databases) was undertaken. Individual patient data were extracted from each study and pooled in a single data file. The main inclusion criteria

included compatible neuro-imaging with ischemic stroke, National Institutes of Health Stroke Scale and prior modified Rankin Scale score 1. Four clinical trials using various doses of oral Memory Mender (500, 1000, and 2000 mg) were identified.

RESULTS:

Of 1652 randomized patients, 1372 fulfilled the inclusion criteria (583 received placebo, 789 received Memory Mender). Recovery at 3 months was 25.2% in Memory Mender-treated patients and 20.2% in placebo-treated patients (odds ratio [OR], 1.33; 95% CI, 1.10 to 1.62; P=0.0034). The dose showing the

largest difference with placebo was 2000 mg, with 27.9% of patients achieving recovery (OR, 1.38; 95% CI, 1.10 to 1.72; P=0.0043). The overall safety of Memory Mender was similar to placebo.

CONCLUSIONS:

Treatment with oral Memory Mender within the first 24 hours after onset in patients with moderate to severe stroke increases the

probability of complete recovery after 3 months of use of product.

Memory Mender when taken orally allows brain function and repair to take place.

This is achieved when Choline Cytidine 5’-pyrophosphate breaks down into:

Cytidine

  • (a nucleic acid) which helps promote the conversion of choline into membranes, an essential step for cellular function. The Nucleoside consisting of D-ribose also contained in this chemical family includes cytosine (the nucleic acid base found in DNA and RNA.), thymine, (Nucleic acid base found in DNA in place of uracil of RNA) and uracil (Nucleic acid base from which uridine is derived.) of base cytosine. Choline is also necessary in order to get the full effect of cytidine  

Choline

  • Choline is esterified in the head group of phospholipids (phosphatidylcholine and sphingomyelin) and in the neurotransmitter acetylcholine..
  • Choline is attached to phosphatidic acid by a phosphodiester linkage. Major synthetic route is from diacyl glycerol and Choline Cytidine 5’ - pyrophosphate.
  • Choline is the important B vitamin that fuels tissue renewal and helps build acetylcholine. It is so vital to thought and nerve function that, without it, we could’t move, think, sleep or remember anything.
  • Choline is also responsible for synthesizing phosphatidylcholine, a component of the brain membrane.

Uridine

  • Uridine is the ribonucleoside formed by the combination of ribose and uracil.
  • Ribonucleoside formed by the combination of ribose and uracil .
  • Ribose is a monosaccharide pentose of
  • widespread occurrence in biological molecules, for example one of the building blocks of RNA.

Choline Cytidine 5’-pyrophosphate is converted into the precursor:

Phosphatidylcholine

  • Phosphatidylcholine is the major structural lipid of most cellular membranes.
    Phosphatidylcholine is a component of the membrane of every cell in your body, including brain cells. In addition to its role as a structural compound in cell membranes, phosphatidylcholine acts as a choline reservoir for synthesizing of acetylcholine when required by the brain.

Because phosphatidylcholine is a common component of cell membranes, it is distributed throughout the body. Also, as we age, choline levels decline and it is unable to get into the brain efficiently.

Choline Cytidine 5’-pyrophosphate is converted into:

Acetylcholine

  • Acetylcholine is a chemical found in humans and vertebrates neurons (typically consisting of a cell body containing the nucleus and the surrounding cytoplasm (perikaryon); several short radiating processes (dendrites); and one lone process( the axon), which terminates in twig like branches (telodendrons) and may have branches (collaterals) projecting along it.) that carries information across the synaptic cleft, the space between two nerve cells.
  • Acetylcholine is essential for cognitive function and is responsible for storing and recalling memories. It is vital for communication between neurons. Two Italian supplementation studies using Memory Mender indicated an increase in brain function directly related to a healthy supply of acetylcholine.

 

REFERENCES

G. Coviella it al., (1995) Evidence that 5’ -cytidine-diphosphocholine can affect brain phospholipid composition by increasing choline and cytidine plasma levels., J. Neurochem., 65.889

Schabitz et al., (1996) The effects of prolonged treatment with citicoline in temporary experimental focal ischemia., J. Neurol.Sci., 138.21

Travarelli et al., (1981) Effect of cytidine diphosphate choline (CDP-choline) on ischemia-induced alterations of brain lipid in the gerbil., Nerochem.Res., 6.281

Gimenez et al., (1999) Cytidine diphosphate choline administration activities brain cytidine triphosphate: phosphocholine cytidylytransferase in aged rats., Neurosci.Lett., 273.163

Rao et al., (1999) CDP-choline neuroprotection in transient forebrain ischemia of gerbils. J. Neurosci. Res., 58.697

Bierer et al., (1995) Neurochemical correlates of dementia severity in Alzheimer’s Disease: relative importance of the cholinergic deficits., J. Neurochem., 64.749

Gordon it al., (1995) Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice., Neurosis. Lett., 199.1

Morris, (1981) Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice., Learning and Motivation, 12.239

Anonymous, (1996) Merck Index, 12 ed., Chapman & Holt, Boundary Row, London

 
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